Cov kws tshawb fawb los ntawm Department of Mechanical and Aerospace Engineering (MAE) ntawm Herbert Wertheim Tsev Kawm Ntawv ntawm Engineering tau tsim ib hom tshiab hemodialysis membrane ua los ntawm graphene oxide (GO), uas yog cov khoom siv monoatomic txheej.Nws yuav tsum tau hloov tag nrho cov kev kho mob ntawm lub raum dialysis ua siab ntev.Qhov kev nce qib no tso cai rau microchip dialyzer txuas rau tus neeg mob daim tawv nqaij.Kev khiav hauj lwm nyob rau hauv cov hlab ntsha siab, nws yuav tshem tawm cov ntshav twj tso kua mis thiab cov hlab ntsha extracorporeal, tso cai rau kev lim ntshav zoo hauv koj lub tsev.Piv nrog rau cov ntaub ntawv polymer uas twb muaj lawm, qhov permeability ntawm daim nyias nyias yog ob qhov kev txiav txim siab dua, muaj cov ntshav sib xws, thiab tsis yooj yim rau scale li polymer membranes.
Xibfwb Knox T. Millsaps ntawm MAE thiab tus thawj coj tshawb fawb ntawm daim nyias nyias project Saeed Moghaddam thiab nws pab neeg tau tsim cov txheej txheem tshiab nrog rau kev sib dhos thiab kev ua kom zoo ntawm lub cev thiab tshuaj lom neeg ntawm GO nanoplatelets.Cov txheej txheem no tsuas yog hloov 3 GO cov khaubncaws sab nraud povtseg rau hauv kev sib koom ua ke nanosheet, yog li ua tiav ultra-siab permeability thiab xaiv."Los ntawm kev tsim ib daim nyias nyias uas muaj qhov permeable ntau dua li nws cov khoom siv lom neeg, lub glomerular hauv qab daim nyias nyias (GBM) ntawm lub raum, peb tau pom lub peev xwm zoo ntawm nanomaterials, nanoengineering, thiab molecular self-assembly."Mogda Dr. Mu said.
Txoj kev tshawb fawb txog kev ua haujlwm ntawm daim nyias nyias hauv hemodialysis scenarios tau tsim cov txiaj ntsig zoo heev.Lub sieving coefficients ntawm urea thiab cytochrome-c yog 0.5 thiab 0.4, raws li, uas yog txaus rau lub sij hawm mus qeeb lim ntshav thaum khaws ntau tshaj 99% ntawm albumin;cov kev tshawb fawb ntawm hemolysis, ntxiv ua kom muaj zog thiab coagulation tau pom tias lawv zoo sib xws rau cov ntaub ntawv lim dej uas twb muaj lawm lossis zoo dua li kev ua haujlwm ntawm cov ntaub ntawv lim dej uas twb muaj lawm.Cov txiaj ntsig ntawm txoj kev tshawb no tau luam tawm ntawm Cov Khoom Siv Txheej Txheem Tshaj Lij (Lub Ob Hlis 5, 2021) nyob rau hauv lub npe "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
Dr. Moghaddam tau hais tias: "Peb tau ua kom pom qhov tshwj xeeb ntawm tus kheej-tsim GO nanoplatelet xaj mosaic, uas ua rau muaj kev siv zog ntau xyoo hauv kev tsim cov graphene-based membranes."Nws yog lub platform siv tau uas tuaj yeem txhim kho qhov qis qis thaum hmo ntuj hauv tsev. "Dr. Moghaddam tam sim no tab tom ua haujlwm ntawm kev tsim cov microchips siv GO membranes tshiab, uas yuav coj kev tshawb fawb los ze zog rau qhov tseeb ntawm kev muab cov cuab yeej siv hemodialysis rau cov neeg mob raum.
Nature's editorial (Lub Peb Hlis 2020) tau hais tias: "Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Hauv Ntiaj Teb kwv yees tias kwv yees li 1.2 lab tus tib neeg tuag ntawm lub raum tsis ua haujlwm txhua xyoo thoob ntiaj teb [thiab qhov tshwm sim ntawm cov kab mob raum kawg (ESRD) yog vim ntshav qab zib thiab kub siab] ….Dialysis Kev sib xyaw ua ke ntawm cov kev txwv ntawm kev siv thev naus laus zis thiab kev them taus kuj txhais tau tias tsawg dua ib nrab ntawm cov neeg xav tau kev kho mob tau nkag mus rau nws. "Tsim nyog cov khoom siv me me uas siv tau yog qhov kev daws teeb meem nyiaj txiag kom muaj sia nyob, tshwj xeeb tshaj yog nyob rau hauv kev txhim kho Tuam Tshoj."Peb daim nyias nyias yog ib qho tseem ceeb ntawm cov khoom siv me me, uas tuaj yeem tsim ua kom pom kev ua haujlwm ntawm lub raum, txhim kho kev nplij siab thiab pheej yig thoob ntiaj teb," said Dr. Moghaddam.
"Kev nce qib loj hauv kev kho mob ntawm cov neeg mob hemodialysis thiab lub raum tsis ua haujlwm yog txwv los ntawm kev siv tshuab membrane.Membrane thev naus laus zis tsis tau ua tiav tseem ceeb hauv ob peb lub xyoo dhau los.Kev nce qib hauv kev siv tshuab membrane yuav tsum txhim kho lub raum lim ntshav.Ib qho khoom siv tau zoo heev thiab xaiv tau, xws li ultra-thin graphene oxide membrane tsim ntawm no, tuaj yeem hloov pauv.Ultra-thin permeable daim nyias nyias tuaj yeem tsis tsuas yog paub cov tshuab lim dej me me xwb, tab sis kuj tseem siv tau thiab siv tau tiag tiag, yog li txhim kho lub neej zoo thiab tus neeg mob. "James L. McGrath tau hais tias nws yog ib tug xibfwb ntawm biomedical engineering ntawm University of Rochester thiab tus kws tsim khoom ntawm lub tshuab tshiab ultra-thin silicon membrane rau ntau yam kev siv tshuaj lom neeg (Nature, 2007).
Cov kev tshawb fawb no tau txais nyiaj los ntawm National Institute of Biomedical Imaging thiab Bioengineering (NIBIB) nyob rau hauv National Institutes of Health.Dr. Moghaddam pab pawg suav nrog Dr. Richard P. Rode, tus kws kho mob tom qab UF MAE, Dr. Thomas R. Gaborski (co-principal investigator), Daniel Ornt, MD (co-principal investigator), thiab Henry C ntawm Department of Biomedical Engineering, Rochester Institute of Technology.Dr. Chung thiab Hayley N. Miller.
Dr. Moghaddam yog ib tug tswv cuab ntawm UF Interdisciplinary Microsystems Group thiab ua tus Nanostructured Energy Systems Laboratory (NESLabs), uas nws lub hom phiaj yog los txhim kho cov kev paub ntawm nanoengineering ntawm kev ua hauj lwm porous lug thiab micro/nanoscale kis physics.Nws coj los ua ke ntau yam kev qhuab qhia ntawm engineering thiab kev tshawb fawb kom nkag siab zoo dua lub physics ntawm micro / nano-scale kis tau tus mob thiab txhim kho cov qauv txuas ntxiv thiab cov tshuab nrog kev ua haujlwm siab dua thiab ua haujlwm tau zoo.
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